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Quick Scroll who can answer that 12.14.05 (2 years ago) #1
why metastasis in bone usually leads to pathological fracture except if the primary tumor is prostatic cancer icon_wink.gif icon_wink.gif icon_wink.gif icon_wink.gif
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Quick Scroll 12.14.05 (2 years ago) #2
becoz prostatic cancers are osteoblastic
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Quick Scroll 12.14.05 (2 years ago) #3
i know that but i mean why it is osteoblastic??
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Quick Scroll 12.15.05 (2 years ago) #4
becuse prostatic carcinomasecretes phosphates enzyme so calsium is deposited is it ok
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Quick Scroll 01.22.06 (2 years ago) #5
AS PROSTATIC METASTASIS IS OSTEOBLASTIC,OTHERS OSTEOPOROTIC/OSTEOCLASTIC.
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Quick Scroll 01.27.06 (2 years ago) #6
what do you mean dear ?do you have another example of osteoblastic tumor??
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Quick Scroll 01.27.06 (2 years ago) #7
Pathological fractures occur when the bone density is less...so in osteolytic tumors with bone resorption the bone strength decreases...so fracture is common.....In prostate cancer it is osteoblastic(osteosclerotic) with more Ca deposition...it could still lead to instability but pathological fractures are less compared with osteolytic metastases...Ca breast can have both osteoblastic or osteolytic metastasis...
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Quick Scroll 01.27.06 (2 years ago) #8
any ref??? dear dr4jc
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Quick Scroll 01.27.06 (2 years ago) #9
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It might be of help....
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Quick Scroll 01.27.06 (2 years ago) #10
Actually the factors are not clear..why they cause such response:

But the consensus is that.. their slow growth allows more time for woven bone repair. In addition, well-differentiated tumors like these(prostatic) are presumably more capable of producing and secreting substances than are poorly differentiated tumors, and it has long been speculated that such well-differentiated tumors might produce some bone-stimulating factor.

Regards,
Akil
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