Page 1 of 1: BETA BLOCKERS

shabana · Credits: 11520 My Scrapbook

beta blockers are contraindicated with heartfailure

ecept in .........

the following cases

iin heartfailure (mild or moderate)

and only with memebers

Carvediolol dose 3.25 -6.25mg once or twice /day

bisprolol 1.25 mg /day

metoprolol

5_50mg / day

the benefit of beta blockers is

in some cases of heart failure there is sympathetic overactivity so we use beta blockers only to protect the heart from it

carvediolol has VD property so decrease the load on the heart

WHEN I ASK THIS QUESTION I HOPED TO RECEIVE ANSWER TO MY QUESTION FROM YOU AS THIS ANSWER IT IS BREIF AND SUMMARIZED AND AND VERY VERY CLEAR

I NEEDED IT VERY MUCH BUT NOW IT IS NO USE TI KNOW IT OHHHHHHHH MY GOD

draditithegreat · Credits: 1248020 My Scrapbook

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shabana · Credits: 11520 My Scrapbook

i think i do that dr

mukhtar · Credits: 278 My Scrapbook

IS METOPROLOL-XL/CR SAFER THAN other METOPROLOL IN CHF

shabana · Credits: 11520 My Scrapbook

really i donot know

younaw · Credits: 396 My Scrapbook

I believe it has to do with the beta blockers having Intrisinic symphathetic Activity, any beta blocker drug that can be given in CHF should have this property.

shabana · Credits: 11520 My Scrapbook

i donot agree with you ...the beta blockers which are given in heart failure are only as i know the three which i menthioned them with the same doses

younaw · Credits: 396 My Scrapbook

Miss Shabana,

Heart failure. The majority of patients in heart failure have a form that is called systolic dysfunction, which means that the contractile function of the heart is depressed (loss of inotropy). Although it seems counterintuitive that cardioinhibitory drugs such as beta-blockers would be used in cases of systolic dysfunction, clinical studies have shown quite conclusively that some specific beta-blockers actually improve cardiac function and reduce mortality. Furthermore, they have been shown to reduce deleterious cardiac remodeling that occurs in chronic heart failure. Although the exact mechanism by which beta-blockers confer their benefit to heart failure patients is poorly understood, it may be related to blockade of excessive, chronic sympathetic influences on the heart, which are known to be harmful to the failing heart.

Different Classes of Beta-Blockers and Specific Drugs

Beta-blockers that are used clinically can be divided into two classes: 1) non-selective blockers (block both b1and b2 receptors), or 2) relatively selective b1 blockers ("cardioselective" beta-blockers). Some beta-blockers have additional mechanisms besides beta-blockade that contribute to their unique pharmacologic profile. The two classes of beta-blockers along with specific compounds are listed in the following table. Additional details for each drug may be found at

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The clinical uses indicated in the table represent both on and off-label uses of beta-blockers. For example, a given beta-blocker may only be approved by the FDA for treatment of hypertension; however, physicians sometimes elect to prescribe the drug for angina because of the class-action benefit that beta-blockers have for angina.

Clinical Uses
Class/Drug HTN Angina Arrhy MI CHF Comments

Non-selective b1/b2
carteolol X ISA;long acting; also used for glaucoma
carvedilol X X a-blocking activity
labetalol X X ISA; a-blocking activity
nadolol X X X X long acting
penbutolol X X ISA
pindolol X X ISA; MSA
propranolol X X X X MSA; prototypical beta-blocker
sotalol X several other significant mechanisms
timolol X X X X primarily used for glaucoma

b1-selective
acebutolol X X X ISA
atenolol X X X X
betaxolol X X X MSA
bisoprolol X X X
esmolol X X ultra short acting; intra or postoperative HTN
metoprolol X X X X X MSA

Abbreviations: HTN, hypertension; Arrhy, arrhythmias; MI, myocardial infarction; CHF, congestive heart failure; ISA, intrinsic sympathomimetic activity, MSA membrane stabilizing activity.

As you could clearly see what can be used in what conditions. I suppose bisoprolol is the only one from your set of choices that can be used in CHF.

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