Page 1 of 1: Ophtho - Bull's eye retinopathy

sajjanshenoy · Credits: 4274 My Scrapbook

This was an AIIMS entrance question :

Which of the following will cause [bleep]'s eye retinopathy :
A. INH
B. Chloroquine
C. Ethambutol
D. Steroids

What is [bleep]'s eye retinopathy that is mentioned in the question ? I don't have any idea about it !

rahulkrishnatry · Credits: 130 My Scrapbook

um... chloroquine!

flowerchildn · Credits: 7753 My Scrapbook

chloroquine ill post the ref later cant remember now

drsweta06 · Credits: 5916 My Scrapbook

chloroquine

BRAVO · Credits: 46105 My Scrapbook

chloroquine

sajjanshenoy · Credits: 4274 My Scrapbook

What is [bleep]'s eye retinopathy ? What are its features ?

maggy · Credits: 691 My Scrapbook

Effect of chloroquine on the eye
Edema, atrophy, abnormal pigmentation (mild pigment stippling to a ‘[bleep]-eye’ appearance), loss of foveal reflex, increased macular recovery time following exposure to a bright light (photo-stress test), elevated retinal threshold to red light in macular paramacular and peripheral retinal areas.

Other fundus changes include optic disc pallor and atrophy, attenuation of retinal arterioles, fine granular pigmentary disturbances in the peripheral retina and prominent choroidal patterns in advanced stage.

D. Visual field defects: Pericentral or paracentral scotoma, central scotoma with decreased visual acuity, rarely field constriction.

The most common visual symptoms attributed to the retinopathy are: reading and seeing difficulties (words, letters, or parts of objects missing), photophobia, blurred distance vision, missing or blacked out areas in the central or peripheral visual field, light flashes and streaks.

Retinopathy appears to be dose related and has occurred within several months (rarely) to several years of daily therapy; a small number of cases have been reported several years after antimalarial drug therapy was discontinued. It has not been noted during prolonged use of weekly doses of the 4-aminoquinoline compounds for suppression of malaria.

Patients with retinal changes may have visual symptoms or may be asymptomatic (with or without visual field changes). Rarely scotomatous vision or field defects may occur without obvious retinal change.

Retinopathy may progress even after the drug is discontinued. In a number of patients, early retinopathy (macular pigmentation sometimes with central field defects) diminished or regressed completely after therapy was discontinued. Paracentral scotoma to red targets (sometimes called "premaculopathy") is indicative of early retinal dysfunction which is usually reversible with cessation of therapy.

A small number of cases of retinal changes have been reported as occurring in patients who received only hydroxychloroquine. These usually consisted of alteration in retinal pigmentation which was detected on periodic ophthalmologic examination; visual field defects were also present in some instances. A case of delayed retinopathy has been reported with loss of vision starting one year after administration of hydroxychloroquine had been discontinued.

wondergirl · Credits: 13337 My Scrapbook

[bleep] eye retinal lesion----chloroquine

optic neuritis----ethambutol

parin · Credits: 14680 My Scrapbook My Reading List 1 Books

It is the characteristic lesion d/t chloroquine toxicity...

It consists of a central hyperpigmentation beneath the foveola, surrounded by a concentric depigmented circular zone, which in turn is encircled by an area of increased pigmentation. The hypopigmentation shows up on the fluorescein angiogram as a hyperfluorescent area, due to an RPE 'window' defect. Once this stage has been reached, rarely progression of visual impairment may occur despite cessation of therapy..

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