Page 1 of 1: physiology--surfactant

manpreet108 · Credits: 30682 My Scrapbook

mudit khanna--AI-05 in its explanation says--
thyroid hormones increases the activity of type 2 pneumocytes.--hence surfactant production.

but i ve read in iams notes that steroid --increases surfactant prodn.
while insulin ,thyroxine --decrease its production..

pls clarify the role of thyroxine related to surfactant prodn--with a ref--as the two statemnets are contradictory.

kalika · Credits: 12517 My Scrapbook My Reading List 12 Books

hi manu !!

insulin decreases the surfactant production by downregulating the rna production for surfactant protein synthesis

thyroid hormones increase the surfactant protein production... n they have got a therapeutic role in ARDS in preterm infants..

manpreet108 · Credits: 30682 My Scrapbook

thanks kalika..
so we infer--

steroid and thyroid increase production .

insulin decreases production.

doctorakash · Credits: 1673 My Scrapbook

see thyroid hormone increases the activity of surfactant---soo rds(due to surfactant depletion)is common in hypothyroidsm.

steroids actiavate the surfactant maturation,especially when the steroids levels r high in both mother n baby at term---soo in a preterm child rds is more common

insulin decreases the surfactant activity,hence diabetic mothers r more prone to rds

to sum it all rds is common in--hypothyroidsm,preterm infant and diabetic mothers.

hope its clear

jayanta · Credits: 37012 My Scrapbook My Reading List 45 Books

OK MANPREET,WE HAD A DETAILED DISCUSSION ON IT.
AKASH HAS ANSWERED IT WELL.

THEROCK · Credits: 1500 My Scrapbook

go according to mudit khanna saying.this is also what books mention

2shar · Credits: 7830 My Scrapbook

hey cud anybody explain
Why increase lung compliance is seen wth saline filled lung?

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