Page 1 of 4: PAEDIATRIC MEDICINE-NEONATOLOGY.

jayanta · Credits: 35983 My Scrapbook My Reading List 45 Books

HYPOTHYROIDISM CAUSES WHICH TYPE OF "HYPERBILIRUBINEMIA?"
1.CONGUGATED.
2.UNCONJUGATED.
3.BOTH.
4.NONE.
ALSO PLEASE EXPLAIN WHY IT IS THE ANSWER.

drdr · Credits: 644 My Scrapbook

unconjugated hyperbilirubinemia due to impaired bilirubin conjugation...

u can browse ur rest of topics either in google or specifically in emedicine.com

BRAVO · Credits: 45704 My Scrapbook

also in kericterus what kind of bilirubin is seen conjugated or unconjugated...i think it should be conjugated...am i right/

jayanta · Credits: 35983 My Scrapbook My Reading List 45 Books

BRAVO,I THINK IT'S UNCONJUGATED BILIRUBIN IN KERNICERUS.
ALSO UOBILINOGEN IS FOUND IN URINE IN KERNICTERUS[BUT NOT UROBILIN-FOUND IN HEPATOCELLULAR INJURY].
AM I RIGHT?

shraddha · Credits: 19590 My Scrapbook

Every baby with hyperbilirubinemia should have a direct fraction measured at least once to rule out direct hyperbilirubinemia. Direct hyperbilirubinemia in the neonate is defined as a direct fraction greater than one third of total bilirubin and is always pathologic. Subsequently, if the hyperbilirubinemia is established as the indirect type, obtaining a direct fraction with every measurement is unnecessary unless the hyperbilirubinemia develops after the expected time frame for typical neonatal hyperbilirubinemia.

so it is conjugated

King75 · Credits: 3084 My Scrapbook

According to me Jaundice in newborn due to hypothyroidism is unconjugated hyperbilirubinemia.
and rightly said by Jayanta, its the same, i.e the unconjugated one that crosses the BBB. (Kernicterus) - lipophilic

Causes of Unconjugated/Pathological Hyperbilirubinemia
Mnemonic - M.D. In Bloody Hyperbilrubinemic Sepsis[/u]

Metabolic Errors - Galactosemia, Criggler Najjar Syndrome I & II

Drugs & Hormone - Hypothyroidism

Incompatabilities - Rh, ABO, other red cell antigen incompatabilities.

Blood causes- Hereditary Spherocytosis, G6PD, Pyruvate Kinase Deficiency, alpha -Thalassemias

Hepatic causes -
1. Extraparenchymal - Cholestasis, Alpha 1 AT deficiency
2. Parenchymal - Hyperalimentation, Hepatitis- Viral,CM

Sepsis- Txoplasmosis, CMV, Syphilis

U could help me adding to the list if i have forgotten any.

Thank u

King75 · Credits: 3084 My Scrapbook

Just to refresh ourselfs on Unconjugated Hyperbilirubunemia; Pathological ~.

* Direct Bilirubin >2mg/dl
* Total Bilirubin >15mg/dl
* Increaswe in levels of bilirubin >0.5mg/dl/hr or 5mg/dl/24hr
* Clinical Jaundice in first 24 hours

Reference : OP Ghai

wondergirl · Credits: 13277 My Scrapbook

shraddha · Credits: 19590 My Scrapbook

Only RxPG members can see links here! Register or Sign In!

thanks
it is unconjugated

jayanta · Credits: 35983 My Scrapbook My Reading List 45 Books

ok,shraddha,
mistakes happen to everybody.
you have tried ,that's all.

		Sign In New User? Sign Up Sign in to access your control panel and messenger!
				TechZone \| SpiderNevi \| HowTo? \| Scrapbook!