Page 1 of 2: Pathology - MOST characteristic cell of a GRANULOMA

decembermist · Credits: 41081 My Scrapbook

a) Lymphocytes
b) Gaint cell
c) epitheloid cell
d) plasma cell

b or c

draditithegreat · Credits: 1247960 My Scrapbook

EPITHELOID CELLS

A granuloma consists of a central collection of modified mononuclear phagocytes which are called epithelioid cells.

Epithelioid cells are derived from macrophages. As macrophages mature to epithelioid cells, they gain secretory and bactericidal capabilities but lose some phagocytic capability.

Morphologically epithelioid cells are large, polygonal and have an eliptical nucleus which contains fine chromatin and 1-2 nucleoli. The cytoplasm can be light or dark.

There are often giant cells in the central part of the granuloma. Giant cells are a conglomeration of epithelioid cells which share the same cytoplasm and have multiple nuclei.

At first most have randomly distributed nuclei (foreign body type giant cell) but later the nuclei are arranged in the periphery (Langhans type giant cell). The central epithelioid and giant cells are surrounded by a rim of lymphocytes, mostly T-helper cells. Lymphocytes are small, oval, basophilic cells with little cytoplasm.

A Langhans' giant cell in the central part of this granuloma is surrounded by epithelioid cells . Note peripherally arranged nuclei in giant cell.

-morpheus- · Credits: 645 My Scrapbook

EPITHELIOD CELLS

dr_siba21 · Credits: 167 My Scrapbook

in case of cat-scratch disease, granuloma formation occur but giant cell is uncommon. hence i think epitheloid cell is most characteristic cell of granuloma

ria_siz18 · Credits: 619 My Scrapbook

i think epitheloid cells.

sea_corel · Credits: 11961 My Scrapbook My Reading List 7 Books

epitheloid cells

sea_corel · Credits: 11961 My Scrapbook My Reading List 7 Books

Giant cells are a "committee" of epithelioid macrophages. Seen here are two Langhans type giant cells in which the nuclei are lined up around the periphery of the cell. Additional pink epithelioid macrophages compose most of the rest of the granuloma

sea_corel · Credits: 11961 My Scrapbook My Reading List 7 Books

These are epithelioid cells around the center of a granuloma. They get their name from the fact that they have lots of pink cytoplasm similar to squamous epithelial cells. Their nuclei tend to be long and stringy.

sea_corel · Credits: 11961 My Scrapbook My Reading List 7 Books

This is a caseating granuloma. Epithelioid cells surround a central area of necrosis that appears irregular, amorphous, and pink. Grossly, areas of caseation appear cheese-like.

sea_corel · Credits: 11961 My Scrapbook My Reading List 7 Books

hope this helps more...

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