Page 1 of 1: patho - hemolysis in G6PD defi.

simv · Credits: 3490 My Scrapbook

A woman with glucose-6-phosphate dehydrogenase (G6PD) deficiency
develops a urinary tract infection. Free radicals generated by
responding neutrophils create an oxidant stress, and RBCs are
rapidly overwhelmed. As soon as intravascular hemolysis begins,
serum levels of which of the following will decrease?

A. Bilirubin
B. C-reactive protein
C. Free iron
D. Haptoglobin
E. Methemoglobin

dana · Credits: 3703 My Scrapbook My Reading List 9 Books

D. Haptoglobin?

drche · Credits: 11979 My Scrapbook My Reading List 10 Books

YA haptoglobin..

dsha · Credits: 3173 My Scrapbook

choice d

dr4jc · Credits: 4396 My Scrapbook

yea as haptoglobin binds to the heme released its free levels reduce in the blood during intravascular hemolysis..ans is D

simv · Credits: 3490 My Scrapbook

Answer is D. Haptoglobin

It a serum protein that promptly binds to free hemoglobin in the serum, forming a tight complex. The haptoglobin-hemoglobin complex is quickly cleared from the blood by the reticuloendothelial system, which allows the hemoglobin to be salvaged instead of lost into the urine. Intravascular hemolysis from any cause is rapidly followed by a dramatic drop in serum haptoglobin.
Bilirubin (choice A) is synthesized in the liver and spleen as an end-product of heme degradation. Serum bilirubin levels would not change until the haptoglobin in the blood was completely saturated, and free hemoglobin began to circulate. In this circumstance, serum bilirubin would increase, not decrease.
C-reactive protein (choice B) is an acute phase reactant produced by the liver in increased quantity in response to inflammation. This patient's urinary tract infection would increase C-reactive protein levels, but the hemolysis would not further affect them.
Serum free iron (choice C) does not change appreciably in intravascular hemolysis. Ferrous iron in the red blood cell is complexed to hemoglobin, and this complex is not broken in hemolysis.
Methemoglobin (an oxidized form of hemoglobin; choice E) increases in the blood along with free hemoglobin in cases of intravascular hemolysis.

zohaib · Credits: 2767 My Scrapbook

Haptoglobin

shabana · Credits: 11520 My Scrapbook

thanks alot dear simv

doctorakash · Credits: 1673 My Scrapbook

remember always that in intravascular hemolysis the following occurs---
hemoglobinemia
hemoglobinuria
hemosiderinuria &
decreased haptoglobulin

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