Page 1 of 3: pharmacology:anti-inflammatory drug in children

trinity · Credits: 13371 My Scrapbook

Anti-inflammatory drug that can be safely used in children is:

1) paracetamol

2) ibuprofen

3) diclofenac

4) nimesulide??

ums · Credits: 294 My Scrapbook

should be paracetamol. ????

trinity · Credits: 13371 My Scrapbook

itsa good analgesic, but according to KDT anti-inflammatory action of paracetamol is NEGLIGIBLE!!!

trinity · Credits: 13371 My Scrapbook

HELP!

doctor82 · Credits: 550 My Scrapbook My Reading List 1 Books

The choice of drugs for children is considerably restricted, and only drugs that have been extensively tested in children should be used. This commonly means that only aspirin, naproxen, or tolmetin should be prescribed. However, the association of Reye's syndrome in children with the administration of aspirin for the treatment of febrile viral illnesses precludes its use in this setting.

The safest NSAID is ibuprofen. Other NSAIDs have failed to demonstrate consistently greater efficacy or safety than ibuprofen. The safety and efficacy of ibuprofen in children have not been established (Goodman & Gilman)

Based on the comprehensive review and analyses of available data, although ibuprofen is the safest of the NSAIDs there appears to be a dose-related risk for GI and renal adverse events. However, at OTC doses of 1200 mg/day or less, the risks appear negligible and there is a relatively wide therapeutic window to the commonly used prescription doses of 2400 - 3200mg/day. ( A review in FDA by International Ibuprofen Society)

This is all the info I could gather. I think it is a controversial issue and we may have to decide by case based on EBM.

But as a conclusion - I will go for ibuprofen

kalika · Credits: 12497 My Scrapbook My Reading List 12 Books

KDT 5th ed page # 177

Ibuprofen has been rated as safest conventional NSAIDs by the spontaneous adverse drug reactions reporting systems in UK

docvin · Credits: 1662 My Scrapbook

ibuprofen is the answer

dr_neo · Credits: 15131 My Scrapbook

Paracetamol (acetaminophen) is not a true anti-inflammatory.
Nimuslide is not safe is children.

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diclofenac has been used much with greated effect as anti-pyretic not ANTI-INFLAMMATORY.

Ibuprofen has been used as anti-inflammatory to great effect in Cystic fibrosis and other diseases also.

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so, i think answer should be IBUPROFEN...

grandmaster · Credits: 4266 My Scrapbook

yes Brufen is the ans.
(Anyone heard about brufen kid tablets 125 mg?)

Well let me add one more question
Do anyone know what was the reason Nimesulide was withdrawn from the Market in 2003-04?
Waiting for ur ans mates

BRAVO · Credits: 45290 My Scrapbook

sinece it causes reye's syndrome in kids..

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