The bacterial resistance to tetracycline is due to Pharmacology MCQ Bank Forums

see your advertisement here

Mobile (PDA) gre ielts gpvts mrcgp mrcog mrcp mrcpath mrcpch mrcs plab toefl usmle

Forums FAQ | Help

		Sign In New User? Sign Up Sign in to access your control panel and messenger!
				TechZone \| SpiderNevi \| HowTo? \| Scrapbook!

DocIndia Forum - Site Related Discussions - Shouts - Library - Lists - Categories

Revision Tools: Eponyms Facts Diseases Syndromes Pathognomics Images Crammer Vocabulary PreviousPapers OSCE Busters GRE

Features Forums Articles Downloads Mnemonics Dictionary Reviews Videos Submit Articles

ZONES>> Hot : MBBS : PrePG : MCQs : Careers : Alt+C : UK : USA : Australia : Canada : Global : OffBeat!

[ Customise this Navigation Bar ]

Alerts - Study Partner - Answers - Seat Reviews - I See - Search Forums | Top Reads Book Shop

Home > > Forums

Email this page

RxPG :: View topic - The bacterial resistance to tetracycline is due to

Pharmacology MCQ Bank Forum Hot - Unanswered

Page 1 of 1: The bacterial resistance to tetracycline is due to

Thread Info | Related Topics | Wiki Page for This Topic

Home -> Forums -> Pharmacology MCQ Bank -> The bacterial resistance to tetracycline is due to

Page 1 of 1

Author

Message

kalika

Credits: 12507

My Scrapbook
My Reading List
12 Books

The bacterial resistance to tetracycline is due to	02.10.06 (2 years ago) #1

The bacterial resistance to tetracycline is due to a. alteration of drug binding site b. inactivation of drug by enzymes c. decreased uptake of drug by bacteria

Post Options: Reply Add Forward Report New

dr4jc

Credits: 4396

My Scrapbook

	02.11.06 (2 years ago) #2

yes the bacteria pump out tetracycline in resistant forms..

Post Options: Reply Add Forward Report New

kalika

Credits: 12507

My Scrapbook
My Reading List
12 Books

	02.11.06 (2 years ago) #3

thnx .. ans givn is B so got confused

Post Options: Reply Add Forward Report New

soniadr25

Credits: 2072

My Scrapbook

02.11.06 (2 years ago) #4

Quote:

Three different specific mechanisms of tetracycline resistance have been identified so far: tetracycline efflux, ribosome protection and tetracycline modification.
Tetracycline efflux is achieved by an export protein from the major facilitator superfamily (MFS). The export protein was shown to function as an electroneutral antiport system which catalyzes the exchange of tetracycline-divalent-metal-cation complex for a proton. In Gram-negative bacteria the export protein contains 12 TMS (transmembrane fragments) whereas in Gram-positive bacteria it displays 14 TMS. Ribosome protection is mediated by a soluble protein which shares homolgy with the GTPases participating in protein synthesis, namely EF-Tu and EF-G. The third mechanism involves a cytoplasmic protein that chemically modifies tetracycline. This reaction takes only place in the presence of oxygen and NADPH and does not function in the natural host (Bacteroides).
The two first mechanisms are the most widespread and most of their genes are normally acquired via transferable plasmids and/or transposons. These two mechanisms were observed both in aerobic and anaerobic Gram-negative or Gram-positive bacteria demonstrating their wide distribution among the bacterial kingdom. To date, about sixty-one tetracycline resistance genes have been sequenced and thirty-two classes of genes identified in non-producers and producers (Streptomyces).

Is "increased efflux of drug" and "decreased uptake" same thing?? If 'yes' then its okay, but if 'not' then (b) seems to be the right answer!

Post Options: Reply Add Forward Report New