Page 1 of 2: Benzodiazepines

wasem · Credits: 8632 My Scrapbook

Benzodiazepines:

(a) Are safer if taken in overdose than are other hypnotics.
True False

(b) Are potent inducers of hepatic enzyme systems.
True False

(c) Do not produce tolerance and physical dependence, unlike barbiturates.
True False

(d) Are sometimes used intravenously in status epilepticus.
True False

(e) Are GABA-receptor antagonists with neuroexcitatory effects.
True False

sea_corel · Credits: 12021 My Scrapbook My Reading List 7 Books

a) true

b) true

c) true

d) true (can be given as iv or rectal solution)

e) false(they have anxiolitics,anticonvulsant,and sedativehypnotic activity.they are agonists)

Benzodiazepines modulate the binding of GABA to the GABAA receptor. Benzodiazepines increase the binding of GABA to GABAA receptors and promote Cl- influx.

prasadkumaresan · Credits: 2294 My Scrapbook

a)true
b)false
c)true
d)true
e)false

ujwals · Credits: 4860 My Scrapbook

Benzodiazepines:

(a) Are safer if taken in overdose than are other hypnotics.
True

(b) Are potent inducers of hepatic enzyme systems.
False

(c) Do not produce tolerance and physical dependence, unlike barbiturates.
True

(d) Are sometimes used intravenously in status epilepticus.
True

(e) Are GABA-receptor antagonists with neuroexcitatory effects.
False

wasem · Credits: 8632 My Scrapbook

thnx

rajju077 · Credits: 35423 My Scrapbook My Reading List 1 Books

Do not produce tolerance and physical dependence, unlike barbiturates.
Who answered true for this? Dont you people know your Pharmacology ?
BEnzos PRODUCE TOLERANCE AND PHYSICAL DEPENDENCe, they arent supposed to be taken more than 3 months, and they are supposed to be weaned off slowly.
Dont ask me how i know, lets say a person who takes it knows it much better than others.
Read your pharma again folks.

sea_corel · Credits: 12021 My Scrapbook My Reading List 7 Books

how about comparison to barbiturates????? :O

nishu9945 · Credits: 9599 My Scrapbook

c) Do not produce tolerance and physical dependence, unlike barbiturates.
False

as BZD's produse tolerance and dependence on long term use but it is less marked when compared to Barbiturates..
but
Question straightforwardly says that the don't produce tolerance which is wrong so it is false..
the correct answer -is they produce far less tolerance and physical dependence, unlike barbiturates.
refer tripathi 5th edition pg 361 point no.6 in BZD's

sea_corel · Credits: 12021 My Scrapbook My Reading List 7 Books

ok got it thanx....

wasem · Credits: 8632 My Scrapbook

The correct answer is

Benzodiazepines:

(a) Are safer if taken in overdose than are other hypnotics. (True)
(b) Are potent inducers of hepatic enzyme systems. (False)
(c) Do not produce tolerance and physical dependence, unlike barbiturates. (False)
(d) Are sometimes used intravenously in status epilepticus. (True)
(e) Are GABA-receptor antagonists with neuroexcitatory effects. (False)

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