Page 1 of 1: O & G - Synchronous tumours - true except

decembermist · Credits: 41091 My Scrapbook

Synchronous tumours - true except

a) endometrial + ovarian commonest
b) incidence = 3%
c) usually squamous in origin
d) if histology is dissimilar - unfavourable prognosis

ans not given

Ans with ref

vimoj · Credits: 27219 My Scrapbook My Reading List 85 Books

ref internet

Synchronous carcinomas involving both the ovary and uterine corpus are relatively uncommon. These tumours represent a diagnostic and therapeutic challenge, particularly if they have similar histology
The presence of simultaneous carcinomas involving both the ovary and uterine corpus is relatively uncommon, and only 0.7?10% of patients with epithelial ovarian or uterine cancers have been found to have simultaneous tumours in large series.1 However, these synchronous tumours represent a diagnostic and therapeutic challenge, particularly if they have a similar histology. Here we present the case of a 34-year-old woman with endometrioid cancers of both ovaries and adenocarcinoma of the uterus

he simultaneous presence of carcinoma in the endometrium and in the ovary may indicate either metastatic disease or independently developing neoplasms. The classification of these lesions either as two separate primary tumours, or as a single primary tumour with a metastasis has implications for patient prognosis and recommendations for therapy. Several large retrospective studies of ovarian endometrioid cancers have demonstrated that the presence of co-existing endometrial adenocarcinoma was not detrimental to the prognosis of patients: in fact it has been suggested that they may indicate better prognosis.2,3,4

Although several morphological criteria have been proposed as guidelines for classification of these lesions, certain cases remain difficult to classify. Eifel et al suggested that if both the tumours were of endometrioid type, the neoplasms represented two separate primaries, and the patient had good prognosis. In contrast, histology of papillary, clear-cell or mucinous type suggested two separate primaries of different morphology, with poorer prognosis. Ulbright showed that concomitant endometrioid carcinoma of the ovary and adenocarcinoma of the endometrium, if moderately or well differentiated, was possibly independent in origin, whereas the poorly differentiated ones were possibly metastatic.6 More recently it was suggested that molecular analysis might be useful in determining the relationship of synchronous uterine and ovarian endometrioid neoplasms. Emmert-Buck et al reported loss of heterozygosity in chromosomes 17q21.3-22 or 11q13 in 10 out of 13 patients who presented with endometrioid tumours in both uterus and ovary. However, eight cases had selective local osteolytic hypercalcemia (LOH) for one tumour site only, suggesting two separate primary tumours.7 Similarly, Lin et al reported high incidence mutations of the human putative protein tyrosine phosphatase (PTEN/MMAC1) gene at chromosome in synchronous endometrial and ovarian carcinomas.8

The mainstay of the treatment is aggressive surgical cytoreduction with total abdominal hysterectomy, bilateral salpingo-oophorectomy, appendectomy and total omentectomy, followed by adjuvant treatment. As with other types of ovarian tumours, the treatment with platinum based chemotherapy has been shown to improve survival in simultaneous tumours. On the other hand, the administration of adjuvant radiotherapy to isolated FIGO Stage Ic uterine adenocarcinoma has been shown to improve outcome. However, it is not clear from the literature whether administration of radiotherapy influences prognosis where concomitant lesions exist

vimoj · Credits: 27219 My Scrapbook My Reading List 85 Books

so answer should be c.. NOT SQUAMOUS

REST ALL TRUE..

decembermist · Credits: 41091 My Scrapbook

thanks a lot

hypomaniac07777 · Credits: 2021 My Scrapbook

squamous...

hypomaniac07777 · Credits: 2021 My Scrapbook

squamous...reference current Obs .and gyn.tr and mg

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