Page 1 of 1: The sick cell syndrome is characterized by

dr_nickash · Credits: 7107 My Scrapbook

The sick cell syndrome is characterized by
a) Hyponatremia.....a??
b) Hypernatremia
c) Hypokalemia
d) Hypekalemia

RxPG_Team · Credits: 19657348 My Scrapbook My Reading List 5 Books

Sick Cell Syndrome

• described the apparent association between hyponatraemia and many acute or chronic illnesses

• attributed to an increase in permeability of cell membranes to Na with or without a decrease in Na pump activity

• another postulated mechanism due to stress-related ADH secretion

• in practice, the hyponatraemia in 'sick cell syndrome' reflects the presence of the underlying disease, and it is this that should be treated, not the hyponatraemia.

josephdhar · Credits: 1655 My Scrapbook

When RBCs sickle, they gain Na+ and lose K+. Membrane permeability to Ca++ increases, possibly due, in part, to impairment in the Ca++ pump that is dependent on adenosine triphosphatase (ATPase). The intracellular Ca++ concentration is 4 times the reference level. The membrane becomes more rigid, possibly due to changes in cytoskeletal protein interactions; however, these changes are not found consistently. Also, whether calcium is responsible for membrane rigidity is not clear.

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