Page 1 of 2: Blast crisis in CML is indicatedby all except

dr_nickash · Credits: 6807 My Scrapbook

Blast crisis in CML is indicatedby all except
a) Lymphadenopathy.......a??
b) High fever
c) Sudden enlargement of spleen
d) Bleeding tendencies

moujik · Credits: 877 My Scrapbook

in all probability ans will b lymphadenopathy.HAR states:progression of cml is associated wth worsening symp.unexplained fever,significant wt loss,incresing dose req of drugs,bone n jt pain,bleeding,trombosis,infections suggest transformation 2 accelerated/blast phase.PHY FINDINGS:moderate splenomegaly persisting despite trt.lymphadenopathy n xtramedullary leukaemic deposition(chloromas) r unusual xcept late in course of dis.

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cant it be ...choice b

moujik · Credits: 877 My Scrapbook

rxpg people plz clarify!

drpsg · Credits: 6168 My Scrapbook

rxpg help

regina · Credits: 119 My Scrapbook

lymphadenopathy is the answer here i m sure of it

regina · Credits: 119 My Scrapbook

lymphadenopathy is the answer here i m sure of it

prodipto · Credits: 300 My Scrapbook

lymphadenopathy

drlouis · Credits: 5374 My Scrapbook

BLEEDING TENDENCIES( lymphadenopathy will be there as in any case of acute leukemia?)

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The diagnosis of blast crisis is based on the presence of 1 or more of the following criteria: (1) blast cell percentage of at least 20% in peripheral blood or bone marrow, (2) blast cell plus promyelocyte percentage of at least 30% in blood or at least 50% in marrow, and (3) extramedullary blastic infiltration. Blast crisis is characterized by cell line heterogeneity, since the blast cells can express a myeloid, lymphoid, megakaryocytic, or, less commonly, erythroid phenotype. About 30% of the CML blast crises are lymphoid and, of these, most have a B lineage, whereas a T-lineage blast crisis is very uncommon. Some studies suggest that analysis of the major breakpoint cluster region methylation status in the chronic and blastic phase could help in predicting the cell lineage (lymphoid or myeloid) of a crisis when the disease is still in the chronic phase because the methylation patterns differ in the 2 processes.

Less than 10% of patients with CML develop blast crisis in organs other than bone marrow. The most common site is the lymph node, although other sites such as skin, bone, soft tissue, periosteum, central nervous system, or the paraspinal space have also been reported. Extramedullary blast crisis may occur during the course of CML either within the context of a frank blastic transformation or as an isolated tumoral infiltrate that heralds an impending blast crisis. Apparently, patients without medullary blastic transformation signs at the time of an extramedullary blast crisis have a much better prognosis than the others.

"http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043%2F0003-9985(2003)127%3Ce249:PQCSLI%3E2.0.CO%3B2"

"http://www.gleevec.com/hcp/pdf/CMLslidekit.pdf"

Lymphoadenopathy is rare in chronic phase of CML, except advanced stages. Lymphadenopathy may signify blast crisis in extramedullary space. Bleeding tendency is there due to thrombocytopenia. Sudden enlargement of spleen very much signifies blast crisis. Unexplained fever is there, but High Fevers?????

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