I passed my step 1 with 99%, so i thought i should share my notes with you all. I am really happy to get that score. Ask me if you want any advise
1. cleft palate: ."failure of fusion of LATERAL PALENTINE, NASAL SEPTUM
2. Cleft lip: Failure of fusion of MAXILLARY, MEDIAL NASAL.
3. Case of alcoholic pancreatic. Elevated AST. AST>ALT, ALT>AST in viral h.
4. Oocyte arrested in prophage of meiosis 1 for years until ovulation.
5. Case of infant of missing kidneys.oligohydramnios.
6. Case of g!rl who has loss of eversion and lifting whole leg to walk: what nerve? A.. common peroneal
7. Loss of sensation of lateral digitsA ..median n.
8. Tumor compressing renal vein, what is result? A.. edema in lower leg, varicocele, esophageal varicies were the choices.
9. Blood supply to descending colon ..Inferior mesenteric artery.
Case of man with bloody diarrhea, biopsy shows psuedopolyps.. ulcerative colitis.
10. What participates in late wound repair.. collagen type 1.
11. A Gross photo of brain :. oligodendrocytes in CNS.
12. Boy with DM
type 1:..absence of B cells in pancreas.
13. Section of lymph node, arrow at paracortex ..houses T cells. A Transection of
14. Reticular Nucleus ..loss of consciousness.
15. Gross photo ofbrainstem, where is : cranial nerve 5?
16. Visual field defect of homonymous hemianopsia, where is the lesion? A .. East the optic chiasm.
17. Knee jerk reflex arc.
18. Where do the cerebral veins drain into : ..find on angiogram.
19. Case of asthmatic given 02 and then P02 drops from 75% to 60%, C02 retention drops, what happened? I put diffusion problem. ~
20. Gross pic of bone. find epipyseal plate.
21. Histology of muscle fiber. Where does ATP and mysosin work?
22. Graph of chemical synapse. Included receptors alpha and beta,
23. Dopamine, Acelyacholine, Norepi and Epinephrine. What drug would activate beta I receptor? -
24. Case of woman going into res. Distress and dies, what happened? .. Pulmonary infarct.
25. Case of sensitivity and specifity .
26. One case of mode. A.. most appearing score. One case of cohort study .A.. forward in time
27. One case of clinical study A ..compares 2 or more treatments.
28. Case of pt having psychotic symptoms, weight loss, agitation, dilated pupils, what drug abused? Amphetamine.
29. Case of premature delivery .Parents do not want child. What do you do? Deliver and attempt resuscitation even if prognosis is bad.
30. Pt tells medical student not to tell anyone about his homosexuality , what do you do? A.. make note in chart for treatment team.
31. Deteriorating alcoholic pt told neighbor DNR if hospitalized, what do you do? Choice is not to or resuscitate. I chose to resuscitate.
32. Case of grieving widow. Depression normal up to one year .
33. Case of alcoholic..thiamine def, destruction of mamillary bodies. What neurotransmitter does cocaine effect?
34. Case of pessimistic, stressful, overly critical man most likely to developA.. MI or gastric ulcer? Case of denial,
35. Case of reaction formationA ..when an unwanted feeling is replaced with
itaTMs opposite.
36. Man who doesndTMt want to exercise after MI says that hedTMII run
the marathon after doing nothing after MI.
37. Case of 6 year old boy starting to wet bed after birth of younger
sister. Mom brings him to Dr. Dr. doesnd£TMt give meds but rather asks questions about problems in family and tells mom she should spend more time with boy.
38. Case of father bringing 10 year old boy to Dr. cuz hed£TMs worried hedTMs
a homo cuz his best friend is another boy A .natural process.
39. Case of denial.
40. Cognitive changes in elderly.
41. Case of yregnant woman having seizures and vomiting, hypertension, erotonuriaA.. eclampsia. -
42. Case of virgin having symptoms of UTI, what is pathogen?A.. E. coli
43. Case ofboy having bloody diarrhea after eating hamburger? A.. E. coli
44. Case of hyperthyroid man with normal TSH, normal radioactive Iodine
uptake, normal thyroid size, whataTMs the problem?A.. exogenous dose of thyroid hormones.
45. What does haloperidol act on? A ..dopamine receptors.
46. Pic ofDNA replication, where is helicase? A.. at the fork unwinding. Few cases of modes of inheritance.
47. One Hardy-Weinberg population genetics problem.
48. Case of pt taking anti-depressive eats cheese and wine having headacheA.. MOA inhibitors + tyramineA.. hypertensive crisis.
49. Case of G6PD deficiency A.. decrease in NADPH leading to hemolytic anema.
50. Case ofMcArdled£TMs dis. What is deficient? Glycolosis or Gluconeogenisis?
51. A~ Case of PKU
52. A ~ Case of Alkaptonuria ..dark urine.
53. A~ Case of Lesch-Nyhan syndrome ..hyperurisemia, def. In HGPRT. ~
54. A ~ Case of elderly woman who doesn’t have marked osteoporosis, why? A .. elevated serum estrogens.
55. A ~ What does estrogen do to lipid profile? A.. increase HDL and decrease LDL. A ~ What is evident in lung section of fetus with
Respiratory Distress syndrome? A~. no surfactant, I chose amniotic fluid. ~
56. A ~ Case of megalobalstic anemia without peripheral neuropathies A.. folate def.
57. A ~ Case of cytic fibrosis with infection A.. Pseudomonas aeruginosa.
58. A ~ What causes goosebumps? A ..pic of hair follicle. Look for erector pili muscle.
59. A ~ What organism survived boiling? A ..Bacillus sp. Spore former. A ~ Case of child with hematuria after sore throat, what titer
is elevated? A ..ASO
60. A ~ What can cause shock? A ..endotoxin A~ Staph is CATALASE +
61. A ~ Case of cellulitis, cocci in chainsA ..strep
62. A ~ Case of enteritis after eating Mexican cheese, gram + coccobacillusA ..I chose staph.
63. A ~ What organism causes pneumonia and grows of charcoal media?A.. Legionella A ~ Infection in burn pt.A ..pseudomonas sp.
64. A ~ What can give most lasting treatment for ulcerA.. antimicrobials.
65. A ~ Case of woman in camping trip having sex with friend now having sore wrists and ankles with multiple lesions on trunk and
arms, aspirate of fluid show spirochetesA ..Iymes dis.
66. A ~ Case of meningitis in AillS pt.A ..cryptococcus sp.
67. A ~ Alpha I antitrypsin def., What causes destruction of lung? A ..unopposed action of elastase.
68. A ~ Most effective vaccineA ..live attenuated? A ~ Case ofDiGeorge synd.
69. A ~ One problem of Complemation-Fixation test-
70. A ~ Case of asthmatic taking drug to improve FEVIA.. broncholilator.
71. A ~ Case ofDown Synd.A.. meiotic DISJUNCTION ofHOMOLOGOUS chromosomes.
72. A ~ Case of DuchennedTMs Ms
Dystorphy
73. A ..defect in dystrophin gene which results in hypertrophy in calf muscle, replaces with fat. Dx with biopsy. A ~
Case of Marfand£TMs Synd. A.. autosomal dominant A ~ ACE inhibitors cause renal damage.
74. A ~ Case of elevated alpha feto-protein in 16 week of pregnancy. Maybe eossible overestimation of fetal age.
75. A ~ STAGE has more prognostic value than grade.
76. A ~ Case of man having back pain and difficulty in urination A ..prostatic adenocarcinoma -metastisis.
77. A ~ Case of man with diff in urination, enlarged prostate but normal psAA .. chronic prostititis?
78. A ~ M spike on electrophoeresis A ..multiple myeloma A ~ Case of mega colonA ..HursprungdTMs dis
79. A ~ Pt with resting tremor A. .substantia nigra. ParkinsondTMs A~ Temporal arteritis can lead to A.. blindness.
Case of girl getting sick after drinking alcohol, what drug is she
(on?A.. metronidozole, disalfuram like effect.
Griseofulvin.
80. A.. interferes with microtubual function, distrupts mitosis.
81. Mechanism of action of Acyclovir ,
82. DOC for CMV A ..ganciclovir, F oscarnet is gancyclovir fails.
Case of pt taking nasal decongestant, what receptor is activated?
83. A .. alpha 1.
84. Side effects ofLithiumA.. hypothyroidism and nephrogenic Dl. ,
85. ACE inhibitors will INCREASE renin due to reflex inhibition.
86. Man with high lipids and hypertension having muscle pains and
myalgias, which drugs are causing symptoms? A.. lovastatin and loop diuretic.
87. Acetazlamide will causeA.. metabolic acidosis.
88. Pt on warfarin has infarct, what other drug is he taking? A .. ehenobarbitol, induces P450 systep.
89. Case of gout what drugs to useA.. colchicine not answer, probenecid was
~ choice. -,
90. Mech. Of action of AllopurinolA.. inhibits xanthine oxidase. Side effect ofPTUA.. agranulocytosis.
91. One half life problem. J Pt has anemia after taking anti malarial drug, what dei Does pt have?A.. G6PD dei
92. One case with cardiac cycle.
93. Case of new born with bleedingA..def. Vit K.
94. Case of child with Necator americanus infection and anemia why? A.. dei of iron.
95. Case ofD. latum infection and anemia why?A.. BI2 dei that leads to megalogblastic anemia.
96. Which landmark distinguishes indirect from direct hernias? A.. inferior eyigastric artery .-
97. Woman on menopause, which is hypofunctioning? A ..ovary
[snip]. Case of person with infections of Candidiasis, what is the defect? A.. cellular immunity .
99. Case of loss of sensation of face, what nerve is affected? A ..Maxillary branch ofCN V.
100. Cystic fibrosis pt with malabsorption, what will you see on biopsy of eancreas? A ..Atrophy
101. Pt taking pills develops acute hepatic reaction based on enzyme levels, AST>AL T, what did she take? A.. acetaminophen.
102. Case of hypothyroidism, high TSH, low thyroid levelsA.. Hashimotod£TMs Case of what happens to liver after ethanol ingestion.A.. fatty change.
103. Case of Diptheria toxin.A ..inhibition of elongation factor .
104. Case of hypertensive having orthostatic hypotension, what drug? A .. Prazosin.A.. alpha I antogonist.
105. Where does anti-cancer effect of Vincristine and Vinblastine work? DNA or RNA ?
106. Case of hypertensive develops Lupus-Like symptoms, what drug is she taking?A.. Hydralazine. Other drugs include: procainamided£:.
107. maple syrup urine disease- 2 questions
108. 2.cherry-red spot- enzyme deficiency
109. 3. ct of the thorax- identification of mediastinal
structures
110. 4. gross brain specimens- LOTS ofthem- sections at different levels
111. 5. brachial plexus questions- muscular deficit
given- identify lesion on a diagram of the plexus 6. drug induced sle
112. 7. prostatic c loads of questions.
113. 8. Iyme disease
116. 11. chest x ray- showing aspirated object-
identify which lobe of lung it has lodged in
117. 12. genetics- transposons
118. 13. CT of abdomen-at the level of pancreas
119. 14. VITAMIN D/ calcium/ phosphate metabolism- NUMBER of questions- rickets
120. 15.mediastinal Anatomy
-
121. 16.stroke localization
122. 17. ethics questions- regarding elderly patient
with dementi and who would make the decision about whether or not to continue icu care-
123. 18. atrophic gastritis
137. 34. benzodiazepines- 3-4 ques on mechanism of action/metabolism/changes in dosage for elderly
138. 35. PCO- history given- had to
know gross
139. 36. sensitivity and odds ratio
140. 37.marfans syndrome
HEY SPIDERMAN, THAT'S AGREAT ACHIEVEMENT!!! CONGRATS YAAR!!! I'M NEW TO THE SEAWORLD OF USMLE
. I HAVE DREAMS OF COMPLETING MY MD IN INDIA & CONTINUE FURTHER STUDIES IN US OR UK?WHAT SHOULD BE MY TRIAL WAY? HOPE U CAN HELP ME? THANX.
Congratulations! Spiderman .You have done wonders.I plan to give USMLE
step1.Please tell me how to go about it.What is the secret of your success......
hello spiderman congrts for ur wonderful score.
plzzz share ur prep tips with all of us...
iam taking step 1in short time,.sooo plzz guide
thanks friend
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.You have done wonders.I plan to give 
