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Endocrinology MCQ Bank Forum Unasnwered
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manipalguySend an Instant Message to manipalguy  




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Quick Scroll mechanism of action of estrogen? 07.13.04 (3 years ago) #1
estrogen acts on
1.nucleus
2mitochondria
3.cell membrane
4.cytoplasmic receptor
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Quick Scroll 07.13.04 (3 years ago) #2
hey kindly give suggestions on this one plz .......
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Quick Scroll 07.14.04 (3 years ago) #3
ans: nucleus.
HARR says:
mech. of oest. actn in target tissues is similar 2 other steroid hrmns:
binding 2 nuclear steroid receptor -> incrsd transcriptn of mRNA -> incrsd protein syn. in cell cytoplasm
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Quick Scroll 07.14.04 (3 years ago) #4
it acts on cytoplasmic receptors , ultimately that complex in internalized oin nuclues and increse mrna synthesis there.. so

so it acts on cytoplasmic receptors
action is mediated through mrna synthesis in nucleus
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Quick Scroll 07.14.04 (3 years ago) #5
estrogen like any other steroid hormone penetrates the cell membrane of the target cells(being steroid it easily passes into cell membrane).within the cytoplasm it combnes with the cytiplasmic receptor to form hormone receptor complex.. whic enters the nucleaus...and then it acts thru DNA. now ....... what should be the answer.... cytoplasmic receptor or nucleus
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Quick Scroll oest. actn. 07.14.04 (3 years ago) #6
ans will b cytoplasm!!(harper)
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Quick Scroll 07.15.04 (3 years ago) #7
what to do man confusion again..!!!!
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Quick Scroll 08.25.04 (3 years ago) #8
Ans.1.Nucleus

Estrogen induce transcription in responce cells .
Steroids, because of lipid solubility enter cells by diffusion across the plasma membrane. Sex hormones, must enter the nucleus before it can bind to the receptor. Hormone activates the receptor protein in nucleus, then, activated protein and hormone create complex and bind to DNA. As a finale function: increased transcription.

Genetics, USMLE Step I, Regulation of Gene Expression, p.39

Question was about action of sex steroid hormones.

Sanya
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Quick Scroll 08.25.04 (3 years ago) #9
ans is definitely cytoplasmic receptor
pls refer KDT pharma.hormones acting thru nuclear receptor are thyroid hormones
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Quick Scroll 10.26.05 (2 years ago) #10
nuclear receptor
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