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RxPG :: View topic - Dna grooves  
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Author Message

mightchillout


DNA GROOVES
hi docs...

can someone explain to me the concept of major and minor grooves in DNA double helix???


i'm reaaly gettin confused on dis one

UNANSWERED: Topics division/frequency in final mbbs question papers?

super7
Aim USMLE Step 1

A groove is a depression..........so on the double-helix,on the side of the molecule there is a shallow depression and a deep depression which are respectively minor and major grooves......see lipinncott[the chap on DNA].

I also remember a drug used to combat cancerous cells,the name's Dactinomycin[Actinomycin D]which lodges itself in the minor groove and stops synthesis..........


mightchillout


i got the point... i had read dat from lippincott....

but i read from some other sources that the groove is basically defined as an angle between glycosidic bonds.... >180 is major and <180 id minor...

this is the confusin part

Cunningham's Manual of Practical Anatomy
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