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RxPG :: View topic - Insulin secretion wrt glucose  
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insulin secretion wrt glucose
hi Rxpgites!!

Insulin secretion After glucose is given intravenously is : LESS/MORE than insulin secretion after the "same" dosage is given orally????

please give an expalnation as well icon_smile.gif

UNANSWERED: Topics division/frequency in final mbbs question papers?

Aim AIPGE 2016

Orally administrated glucose has MORE insulin stimulating effect than i.v. injected glucose (same amount)

Dietary glucose cause secretion of many GI hormones that have insulin stimulating effect. They are GLP, GIP, CCK, Gastrin etc. The increase in plasma glucose (postprandial) also stimulates insulin secretion.

However when intravenously injected the stimulatory effect of the Insulin Stimulating GI hormones are missing.

Ref: Ganong 22/e Pg. 347

Essentials of Medical Pharmacology By KD Tripathi
Extensively revised and updated chapters to include recently introduced drugs, published information and therapeutic practices.
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