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Quick Scroll Gynae 04.22.08 (7 months ago) #1
A lady who suffers from breast CA, best treatment for osteoporosis for her is

a. Estrogen.
b. estrogen and progestrone.
c. bisphosphonate.
d. Ca.
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Quick Scroll 04.22.08 (7 months ago) #2
c........
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Quick Scroll 04.22.08 (7 months ago) #3
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Quick Scroll 04.22.08 (7 months ago) #4
bisphosphonates play a special role in breast ca bone secondaries, which i did not understand. can anyone please enlighten?
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Quick Scroll 04.22.08 (7 months ago) #5
"In addition to inhibiting bone resorption, bisphosphonates have also been shown to exhibit antitumour effects. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in cultured human breast cancer cells. In addition, bisphosphonate treatment interferes with breast cancer cell adhesion to bone matrix, and inhibits cell migration and invasion. The combination of bisphosphonates with other anticancer drugs such as the taxoids markedly enhances these effects. These newly recognized direct actions of bisphosphonates on breast cancer cells indicate that these agents may have a greater role to play in treatment of patients suffering from cancers with a propensity to metastasize to bone."
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Quick Scroll 04.22.08 (7 months ago) #6
thank you very much. very helpful
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