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Quick Scroll lab diagnosis of chronic hepatitis B and carrier state 04.27.08 (5 months ago) #1
how can you distinguish between chronic hepatitis HBV and HBV carrier based on laboratory investigations?
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Quick Scroll Re: medicine----chronic hepatitis and carrier 04.29.08 (5 months ago) #2
shabana wrote:
HI MY FRIENDS


how can you distinguish((( laboratory))) between chronic hepatitis HBV and HBV carrier


chronic hepatitis B is of two types
chronic active i.e HBeAg +ve
chronic inactive i.e HBeAg -ve

In HBeAg positive chronic hepatitis B, HBeAg and high titres of HBV DNA are present in serum, and anti-HBe is undetect-able.

In HBeAg negative chronic hepatitis B anti-HBe is present and HBeAg is absent in serum; HBV DNA is present in serum although large fluctuations in levels can occur.


In the inactive HBsAg carrier state, HBsAg and anti-Hbe are present in serum, but serum aminotransferase levels are persistently normal . Such patients have either low or undetectable levels of HBV-DNA in serum.
So its easy to differentiate HBV carrier 4om chronic active Hep B but difficult in case of chronic inactive Hep B

The differentiation of inactive HBV carrier state from HBeAg negative chronic hepatitis B requires serial testing of serum aminotransferase and HBV-DNA levels

alternatively we can always differentiate carrier state 4om chronic hep b with the help of liver biopsy in which carriers will show no change while chronic hepatitis liver will show characteristic changes
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Quick Scroll 04.30.08 (5 months ago) #3
thanks alot dear supergenius
really thanks alt dear

iam very grateful for you icon_biggrin.gif icon_biggrin.gif icon_biggrin.gif icon_biggrin.gif
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Quick Scroll 05.01.08 (5 months ago) #4
but CAN i say that this carrier can be case of chronic active or inactive hepatitis oneday?
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