Page 1 of 1: Safe anti malarial drug in pregnancy?

Akil · Credits: 28144 My Scrapbook

Which of the following is safest in pregnancy for prophylaxis of P.vivax infection?
Chloroquine
Chloroquine + Primaquine
Primaquine

Chloroquine?

drjanak · Credits: 3151 My Scrapbook

Williams Obstetrics 22nd Ed – Section VIII- Medical & Surgical Complications, Chapter 58 - Infections
Malaria
Prophylaxis
Pregnant women in areas in which malaria is endemic are primary candidates for chemoprophylaxis to prevent the adverse consequences of infection during pregnancy. Cot and colleagues (1992) showed that chloroquine chemoprophylaxis decreased placental infection in asymptomatic infected women to 4 percent compared with 19 percent of untreated controls. Alternatively, a simple control strategy of intermittent presumptive treatment with sulfadoxine-pyrimethamine at the start of the second and third trimesters significantly reduces maternal anemia, placental parasitemia, and low-birthweight, although HIV-infected women may require additional doses (Parise and co-workers, 1998; Verhoeff and associates, 1998
Pregnant women should not take doxycycline or the combination of atovaquone and proguanil for chemoprophylaxis.
Chemoprophylaxis is recommended for travel to endemic areas. If chloroquine-resistant falciparum or vivax malaria has not been reported, prophylaxis is initiated 1 to 2 weeks before the endemic area is entered. Chloroquine, 500 mg of base, is given orally once a week, and this is continued until 4 weeks after return to nonendemic areas (Bradley and Warhurst, 1995; Centers for Disease Control and Prevention, 2003b; Wyler, 1993).
Travel to areas endemic for chloroquine-resistant strains is discouraged during early pregnancy, after which mefloquine prophylaxis is given (Centers for Disease Control and Prevention, 2003a).

Hence safest is chloroquine

Akil · Credits: 28144 My Scrapbook

G&G also says primaquine is contraindicated in pregnancy!

hariompriyom · Credits: 5841 My Scrapbook

CHLOROQUINE .

PRIMAQUINE IS ABSOLUTELY C/I IN PREGNANCY.

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