Page 1 of 5: CONTROVERTIAL QUESTIONS

dr_zook81 · Credits: 709 My Scrapbook

FRIENDS LETS POOL IN ALL THE CONTROVERSIAL QUESTIONS HERE IN ONE SINGLE POST THAT WOULD A LOT OF BENEFIT TO ME, YOU AND OTHERS..PEOPLE PLEASE POST YOUR ANSWERS ALONG WITH THE REFERENCE SO IT BECOMES MORE CONVINCING (IF YOU ARE LIKE ME WHO NEEDS TO 'SEE IT TO BELIEVE IT')
LETS HELP EACH OTHER OUT !!

dr_zook81 · Credits: 709 My Scrapbook

Q. 35 MAY 2006 AIIMS
the mechanism by which cholera might be maintained during the intervals between peek cholera seasons is:
a. carrier state in animals
b. carrier status in man
c. an environmental reservoir
d. continuous transmission in man

answers and the explanations provided are different in ashish amit vs. arvind aroma - Microbiology review

jayakrishnav55 · Credits: 12663 My Scrapbook

anser is d.continuous transmission in man.speed notes . ananthnarayan 7 th ed.in endemic areas , it may be transmitted by continous trnsmission of subclinical or mild infection.pl give the ansers given is ashish amit and pulse Microbiology . what does acrioss micribiology say. interesting question.

dr_zook81 · Credits: 709 My Scrapbook

good references on that..but listen to what arvind arora has to say on this.
Q.296 AIIMS MAY 2002 (IN ARVIND ARORA MICRO) PG 108
TRUE ABOUT V.CHOLERAE IS.
a.one attack of v.cholera gives life long immunity
b.affect adults and children with equal propensity in non-endemic areas
c.in between epidemics, carrier state maintains the organism
d.pathogenecity of 0-139 vibrio is due to O antigen

EXPLANATION. ans given as D
"i know this answer is going to raise many eyebrows"

) :NOT ME:
choice C: though carrier state exists, it is rare
and they are not able to maintain organism in between epidemics
maintained between epidemics in its natural habitat ie. coastal waters and brackish estuaries

EXPLANATION FOR D:
most controvertial..referecne given from harrison's 16th Ed 911
v.cholerae 0-139 bengal is in fact virtually identical to El. tor except for
1.production of O139 LPS
2.an immunologically related O-antigen polysaccaride capsule

jugunu · Credits: 875 My Scrapbook

Hi,
this is ques no.103 from bhatias patho test and q83 from deepak mishra's patho review book.

DNA probe is of great value in the identification of gene in all of the following neoplasms except--
1.neuroblastoma.
2.breast cancer.
3.lymphomas
4.gliomas

my confusion is last two options bcoz bhatias give ans as lymphomas and deepak mishra's book on pg-94 gives ans as gliomas.

pl help

jugunu · Credits: 875 My Scrapbook

another ques is q105 of bhatias patho test & q152 from deepak mishra's patho book on pg-99 ,q152

BIPHASIC PATTERN on histology is seen in which tumour?
1.rhabdomyosarcoma
2.synovial sarcoma
3.osteosarcoma.
4.neurofibroma

bhatias give ans as synovial sarcoma whereas deepak mishra gives ans as neurofibroma

pl help.

drchin · Credits: 271 My Scrapbook

Histopathology of synovial sarcoma t[x,18].
Two cell types can be seen microscopically in synovial sarcoma. One fibrous type, known as a spindle or sarcomatous cell, is relatively small and uniform and found in sheets. The other is epithelial in appearance. Classical synovial sarcoma has a biphasic appearance with both types present. Synovial sarcoma can also appear to be poorly differentiated or to be monophasic fibrous, consisting only of sheets of spindle cells. Some authorities state that, extremely rarely, there can be a monophasic epithelial form which causes difficulty in differential diagnosis.

dr_zook81 · Credits: 709 My Scrapbook

HERE'S WHAT I COULD COME UP WITH DIAGNOSIS OF GLIOMA WITH DNA PROBE

Institut Curie and Inserm research scientists and physicians have just shown that precise knowledge of alterations in chromosome 1 can be used to improve the treatment of gliomas, the most frequent brain tumors in adults. Diagnosis and treatment of these tumors are difficult because of their heterogeneity and variable malignancy. Using DNA chips, the authors of this report were able to distinguish the tumors with the best prognosis, whose chromosome 1 has undergone a specific deletion. Screening for these deletions should be incorporated into standard diagnostic tests by the end of 2005.

These results are published in the September 2005 issue of Annals of Neurology.

dr_zook81 · Credits: 709 My Scrapbook

The MET (also known as c-met) proto-oncogene located at 7q31-34 has been shown to be amplified in human gliomas, and activating mutations within the tyrosine kinase domain of MET have been causally related to tumorigenesis in hereditary papillary renal cell carcinoma. To elucidate the role of MET gene in glioma formation, sporadic gliomas from 11 patients were examined for MET gene mutations and allelic duplications or deletions by polyermase chain reaction-single strand conformational polymorphism analysis and fluorescence in situ hybridization. Three of 11 sporadic gliomas showed a deletion of one copy of the MET gene, and a specific MET gene missense mutation in the remaining gene copy was detected in one of those tumors.

dr_zook81 · Credits: 709 My Scrapbook

regarding ur second question

Japanese Journal of Clinical Oncology
We report a case of synovial sarcoma (SS) showing unusual histology at distant sites. A 47-year-old man was aware of a tumor on the sole of his left foot. After preoperative chemotherapy with a diagnosis of SS, wide excision was performed. During postoperative chemotherapy, multiple tumorous lesions developed in the bone (including the whole spine) and both lungs. The patient died 1 year later. Histologically, the excised tumor of the foot showed a biphasic cellular pattern typical of SS, whereas at autopsy the bone and lung lesions were composed only of undifferentiated small round cells with cytoplasmic fibrillar processes. Homer-Wright rosettes were also observed.

cross re-checked with multiple sites on Google..

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