Page 1 of 2: add a point here

tinwintin · Credits: 2153 My Scrapbook

hey friends , i am starting a thread here,as we all know there is really too much information overload,we have notes coming in from all ends,and the basic thing is too put all the information in our grey space....well tht can be done if we are active in our learning process rather than passive readers...an attempt in this direction is this thread.....many times we come across some topics that are important,or could be asked in the future......these kind of topics will be presented here.....if anyone wants to start a topic that is bugging them...they r free to do so...then everybody keeps adding facts till the topic is done...and everybody is perfect about the topic...remember its important that you be active in this rather than passive readers...do join in if u find it useful

tinwintin · Credits: 2153 My Scrapbook

heres an example.......

topic essential mixed cryoglobulinemia

cryoglobulins are cold precipitable monoclonal or polyclonal immunoglobulins
seen in hepatitis c infection

tinwintin · Credits: 2153 My Scrapbook

can be seen in multiple myeloma ,liver disease,connective tissue disorders

complexes are found of hepatitis c,polyclonal hepatitis c and monoclonal igm rheumatoid factor

tinwintin · Credits: 2153 My Scrapbook

treatment is control of hepatitis c infection ....IFN alpha AND RIBAVIRIN

tinwintin · Credits: 2153 My Scrapbook

main manifestations are

CUTANEOUS VASCULITIS

ARTHRITIS.....
PERIPHERIAL NEUROPATHY

GLOMERULONEPHRITIS.....MOST CASES SHOW MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

tinwintin · Credits: 2153 My Scrapbook

tinwintin · Credits: 2153 My Scrapbook

end of topic....
new topic ......synovial sarcoma......join in friends

aimit · Credits: 1154 My Scrapbook

Its soft tissue sarcoma.More in young and adult,peak 30yr,M>F(1.2:1),on histo cells similar to synovial cells hence name.Not always arise from synovium.Mostly in soft tissue near jt of arm n legs,may occur in brain,prostate,heart.Translocation tx:18(p11.2,q11.2) result in SYT-SXX Fusion protein causing gene dysregulation.SYT of chr18 and SXX of chrX.Two types 1.Fibrous-having spindle cells 2.Epithelial cell type. Classical synovial sarcoma have mixed type cells.T/t is mainly surgical.Chemotherapy-mainly doxorubicin,etoposide,it prolong survival.Radiotherapy limited role,decreases burden of tumour cells.

aimit · Credits: 1154 My Scrapbook

Next topic imp CD markers for imp cancers. esp those which will help in differentiating b/w close options in exam hall.

tinwintin · Credits: 2153 My Scrapbook

some important concepts regarding cds for haematological malignancies.....

cd 5 is positive only in mantle cell and CLL

CD 23 IS POSITIVE IN CLL BUT NEGATIVE IN MANTLE.....ALSO ABSENT IN HAIRY CELL

CD 22 IS NEGATIVE IN CLL BUT POSITIVE IN MANTLE

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