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Nagging Q Forum Hot - Library - Unanswered
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Quick Scroll high 1st pass metabolism 09.17.04 (3 years ago) #1
pgi
high 1st pass metabolism seen in

a. propanolol
b. acebutalol
c. labetalol
d. amitrptilline

ans is a] and d] or all??
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Quick Scroll 09.17.04 (3 years ago) #2
ans will b propanolol.

drugs with high first pass met:
propanolol
verapamil
salbutamol
morphine
pethidine
methyl testosterone
propoxyphene


ISOPRENALINE
TESTOSTERONE
LIGNOCAINE
HYDROCORT-------- these r not given orally
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Quick Scroll 09.17.04 (3 years ago) #3
drugs wth intermediate 1st pass met

aspirin
quinidine
desipramine
NORTRIPTYLINE
chlorpromazine
pentazocine
metoprolol

wth low 1st pass met

phenobarb
phenylbutazne
tolbutamide
theophylline
pindolol
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Quick Scroll 09.17.04 (3 years ago) #4
but list of drugs causing high 1st pass metabolism includes amitriptylline too--kdt 26
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Quick Scroll 09.17.04 (3 years ago) #5
r u sure?? i checked the list .the above list is from kdt 5th ed pg 25
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Quick Scroll 09.18.04 (3 years ago) #6
ya its there in 4th ed
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Quick Scroll 10.06.07 (10 months ago) #7
this is from katzung. bioav of propranolol is 30% whereas it is 31-61% for amitryptiline(pg 179 and 479)so the ans is propranolol
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Quick Scroll 10.11.07 (10 months ago) #8
nandanr wrote:
this is from katzung. bioav of propranolol is 30% whereas it is 31-61% for amitryptiline(pg 179 and 479)so the ans is propranolol
propranolol
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Quick Scroll 05.17.08 (3 months ago) #9
hmm
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Quick Scroll 05.22.08 (3 months ago) #10
yup checked it from Katzung and the answer is Propranolol
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