Normal Laboratory Values and Ranges For MRCP Question Papers Date: Monday, July 07 @ 04:27:45 IST Topic: MRCP Part 1 Print this page Haematology Full blood count Haemoglobin (males) 13.0 – 18.0 g/dL Haemoglobin (females) 11.5 – 16.5 g/dL Haematocrit (males) 0.40 – 0.52 Haematocrit (females) 0.36 – 0.47 MCV 80 – 96 fL MCH 28 – 32 pg MCHC 32 – 35 g/dL White cell count 4 – 11 x 109/L White cell differential: Neutrophils 1.5 – 7 x 109/L Lymphocytes 1.5 – 4 x 109/L Monocytes 0 – 0.8 x 109/L Eosinophils 0.04 – 0.4 x 109/L Basophils 0 – 0.1 x 109/L Platelet count 150 – 400 x 109/L Reticulocyte count 25 – 85 x 109/L OR 0.5 – 2.4% Erythrocyte sedimentation rate Westergren Under 50 years: Males 0 – 15 mm/1st hr Females 0 – 20 mm/1st hr Over 50 years: Males 0 – 20 mm/1st hr Females 0 – 30 mm/1st hr Plasma viscosity (25°C) 1.50 – 1.72 mPa/s Coagulation Screen Prothrombin time 11.5 – 15.5s International normalised ratio <1.4 Activated partial thromboplastin time 30 – 40s Fibrinogen 1.8 – 5.4 g/L Bleeding time 3 – 8m Coagulation Factors Factors II, V, VII, VIII, IX, X, XI, XII 50 – 150 IU/dL Factor V Leiden Von Willebrand factor 45 – 150 IU/dL Von Willebrand factor antigen 50 – 150 IU/dL Protein C 80 – 135 IU/dL Protein S 80 – 120 IU/dL Antithrombin III 80 – 120 IU/dL Activated protein C resistance 2.12 – 4.0 Fibrin degradation products < 100 mg/L D-Dimer screen < 0.5 mg/L Haematinics Serum iron 12 – 30 µmol/L Serum iron-binding capacity 45 – 75 µmol/L Serum ferritin 15 – 300 µg/L Serum transferrin 2.0 – 4.0 g/L Serum B12 160 – 760 ng/L Serum folate 2.0 – 11.0µg/L Red cell folate 160 – 640 µg/L Serum haptoglobin 0.13 – 1.63 g/L Haemoglobin electrophoresis: Haemoglobin A > 95% Haemoglobin A2 2 – 3% Haemoglobin F < 2 % Chemistry Serum sodium 137 – 144 mmol/L Serum potassium 3.5 – 4.9 mmol/L Serum chloride 95 – 107 mmol/L Serum bicarbonate 20 – 28 mmol/L Anion gap 12 – 16 mmol/L Serum urea 2.5 – 7.5 mmol/L Serum creatinine 60 – 110 µmol/L Serum corrected calcium 2.2 – 2.6 mmol/L Serum phosphate 0.8 – 1.4 mmol/L Serum total protein 61 – 76 g/L Serum albumin 37 – 49 g/L Serum total bilirubin 1 – 22 µmol/L Serum conjugated bilirubin 0 – 3.4 µmol/L Serum alanine aminotransferase 5 – 35 U/L Serum aspartate aminotransferase 1 – 31 U/L Serum alkaline phosphatase 45 – 105 U/L (over 14 years) Serum gamma glutamyl transferase 4 – 35 U/L (< 50 U/L in males) Serum lactate dehydrogenase 10 – 250 U/L Serum creatine kinase (Males) 24 – 195 U/L Serum creatine kinase (Females) 24 – 170 U/L Creatine kinase MB fraction < 5% Serum troponin I 0-0.4 µg/L Serum troponin T 0 – 0.1 µg/L Serum copper 12 – 26 µmol/L Serum caeruloplasmin 200 – 350 mg/L Serum aluminium 0-10 µg/L Serum magnesium 0.75 – 1.05 mmol/L Serum zinc 6 – 25 µmol/L Serum urate (males) 0.23 – 0.46 mmol/L Serum urate (females) 0.19 – 0.36 mmol/L Plasma lactate 0.6 – 1.8 mmol/L Plasma ammonia 12 – 55 µmol/L Serum angiotensin-converting enzyme 25 – 82 U/L Fasting plasma glucose 3.0 – 6.0 mmol/L Haemoglobin A1 C 3.8 – 6.4% Fructosamine < 285 µmo/L Serum amylase 60 – 180 U/L Plasma osmolality 278 – 305 mosmol/Kg Urine Albumin/creatinine ratio (untimed specimen) <3.5 mg/mmol (males) <2.5 mg/mmol (females) Lipids and Lipoproteins The target levels will vary depending on the patient’s overall cardiovascular risk assessment. Serum cholesterol: < 5.2 mmol/L Serum LDL cholesterol: < 3.36 mmol/L Serum HDL cholesterol: > 1.55 mmol/L Fasting serum triglyceride 0.45 – 1.69 mmol/L Blood Gases (breathing air at sea level) Blood H+ 35 – 45 nmol/L pH 7.36 – 7.44 PaO2 11.3 – 12.6 kPa PaCO2 4.7 – 6.0 kPa Base excess ± 2 mmol/L Carboxyhaemoglobin: Non-smoker < 2% Smoker 3 – 15% Endocrinology Adrenal steroids Blood Serum aldosterone (normal diet) Upright (4h) 330 – 830 pmol/L Supine (30m) 135 – 400 pmol/L Serum cortisol: 09.00h 200 – 700 nmol/L 22.00h 50 – 250 nmol/L Overnight dexamethasone suppression test (after 1mg dexamethasone) Serum cortisol < 50 nmol/l Low dose dexamethasone suppression test (2 mg/day for 48h) Serum cortisol < 50 nmol/L After insulin-induced hypoglycaemia (blood glucose < 2.2 mmol/L) Serum cortisol > 550 nmol/L and 200 nmol/L greater than baseline Plasma 11 – deoxycortisol 24 – 46 nmol/L Serum dehydroepiandrosterone (09.00) 7 – 31 nmol/L Serum dehydroepiandrosterone sulphate: (Males) 2 – 10 µmol/L (Females) 3 – 12 µmol/L Serum androstenedione (adults) Males 1.6 – 8.4 nmol/L Females 0.6 – 8.8 nmol/L Post menopausal females 0.9 – 6.8 nmol/L Serum 17-hydroxyprogesterone: Males 1 – 10 nmol/L Females Follicular 1 – 10 nmol/L Luteal 10 – 20 nmol/L Serum oestradiol Males < 180 pmol/L Females Post-menopausal < 100 pmol/L Follicular 200 – 400 pmol/L Mid-cycle 400 – 1200 pmol/L Luteal 400 – 1000 pmol/L Serum progesterone Males < 6 nmol/L Females Follicular < 10 nmol/L Luteal > 30 nmol/L Serum testosterone Males 9 – 35 nmol/L Females 0.5 – 3 nmol/L Serum dihydrotestosterone Males 1- 2.6 nmol/L Females 0.3 – 9.3 nmol/L Serum sex hormone binding protein Males 10 – 62 nmol/L Females 40 – 137 nmol/L Urine Aldosterone 14 – 53 nmol/24h Cortisol 55 – 250 nmol/24h Plasma angiotensin II 5 – 35 pmol/L Plasma renin activity Recumbent 1.1 – 2.7 pmol/ml/h Erect after 30m 3.0 – 4.3 pmol/ml/h Pancreatic and gut hormones Plasma gastrin < 55 pmol/L Plasma or serum insulin: Overnight fasting < 186 pmol/L After hypoglycaemia (Blood glucose < 2.2 mmol/L) < 21 pmol/L Plasma vasoactive intestinal polypeptide < 30 pmol/L Plasma pancreatic polypeptide < 300 pmol/L Plasma glucagon < 50 pmol/L Anterior pituitary hormones Plasma adrenocorticotrophic hormone 09.00 < 18 pmol/L Plasma follicle stimulating hormone Males 1 – 7 U/L Females Follicular 2.5 – 10 U/L Midcycle 25 – 70 U/L Luteal 0.32 – 2.1 U/L Post-menopausal > 30 U/L Plasma growth hormone Basal, fasting and between pulses < 1 mU/L After hypoglycaemia > 40 mU/L Plasma luteinizing hormone Males 1 – 10 U/L Females Follicular 2.5 – 10 U/L Midcycle 25 – 70 U/L Luteal 1 – 13 U/L Post-menopausal > 30 U/L Plasma prolactin < 360 mU/L Plasma thyroid stimulating hormone 0.4 – 5 mU/L Posterior pituitary hormones Plasma antidiuretic hormone 0.9 – 4.6 pmol/L Thyroid hormones Plasma thyroid binding globulin 13 – 28 mg/L Plasma thyroxine (T4) 58 – 174 nmol/L Free T4 10 – 22 pmol/L Tri-iodothyronine (T3) 1.07 – 3.18 nmol/L Free T3 5 – 10 pmol/L Serum TSH receptor antibodies < 7 U/L Serum antithyroid peroxidase < 50 IU/mL Serum thyroid receptor antibodies < 10 U/L Catecholamines (Plasma recumbent with venous catheter in place for 30m prior to collection of sample) Adrenaline 0.03 – 1.31 nmol/L Noradrenaline 0.47 – 4.14 nmol/L Urine Vanillyl mandelic acid 5 – 35 µmol/24h Dopamine < 3100 nmol/24h Adrenaline < 144 nmol/24h Noradrenaline < 570 nmol/24h Hydroxyindole acetic acid < 70 µmol/24h Others Plasma parathyroid hormone 0.9 – 5.4 pmol/L Plasma calcitonin < 27 pmol/L Serum cholecalciferol (vitamin D3) 60 – 105 nmol/L Serum 25 – OH – cholecalciferol 45 – 90 nmol/L Age-related insulin like growth factor – 1 13 – 15 yrs 9.3 – 56.0 nmol/L 16 – 18 yrs 9.3 – 56.0 nmol/L 20 – 40 yrs 7.5 – 37.3 nmol/L 40 – 60 yrs 5.6 – 23.3 nmol/L >60 yrs 3.3 – 23.3 nmol/L Immunology / Rheumatology Complement C3 65 – 190 mg/dL Complement C4 15 – 50 mg/dL Total haemolytic (CH50) 150 – 250 U/L Serum C-reactive protein < 10 mg/L Serum immunoglobins IgG 6.0 – 13.0 g/L IgA 0.8 – 3.0 g/L IgM 0.4 – 2.5 g/L IgE <120 kU/L Serum β2 – micro globulin < 3 mg/L Autoantibodies (all serum) Adrenal Negative at 1:10 Dil. Anticentromere antibodies Negative at 1:40 Dil. Anticardiolipin antibody IgG 0 – 23 IgM 0 - 11 Anti double-stranded DNA (ELISA) 0 – 73 U/mL Antineutrophil cytoplasmic antibodies Anti Proteinase 3 Negative Anti MPO Negative Antinuclear antibodies Negative at 1:20 Dil. ENA Negative Gastric parietal cells Negative at 1:20 Dil. Interstitial cells of testis Negative at 1:10 Dil. Jo-1 Negative La Negative Mitochondrial Negative at 1:20 Dil. RNP Negative Scl-70 Negative Ro Negative Skeletal muscle Negative at 1:60 Dil. Sm Negative Smooth muscle Negative at 1:20 Dil. Thyroid colloid and microcosmal antigens Negative at 1:10 Dil. Rheumatoid factor < 30 k IU/L Tumour Markers Serum alpha-fetoprotein <10 kU/L Serum carcinoembryonic antigen < 10 µg/L Serum neurone specific enolase < 12 µg/L Serum prostate specific antigen Males over 40 <4 µg/L Males under 40 <2 µg/L Serum human chorionic gonadotrophin < 5 U/L Serum CA 125 < 35 U/mL Serum CA 19 – 9 < 33 U/mL Therapeutic Drug Levels Plasma aminophylline 10 – 20 µg/mL Plasma carbamazepine 34 – 51 µmol/L Blood ciclosporin 100 – 150 nmol/L Plasma digoxin (taken at least 6h post dose) 1 – 2 nmol/L Plasma ethosuximide 280 – 710 µmol/L Blood gentamicin (peak) 5 – 7 µg/ml Serum lithium 0.5 – 1.5 mmol/L Serum phenobarbital 65 – 172 µmol/L Serum phenytoin 40 – 80 µmol/L Serum primidone 23 – 55 µmol/L Plasma theophylline 55 – 110 µmol/L Cerebro-spinal fluid Opening pressure 50 – 180 mm H2O Total protein 0.15 – 0.45 g/L Albumin 0.066 – 0.442 g/L Chloride 116 – 122 mmol/L Glucose 3.3 – 4.4 mmol/L Lactate 1 –2 mmol/L Cell count ≤ 5 mL-1 Differential: Lymphocytes 60 – 70% Monocytes 30 – 50% Neutrophils None IgG/ALB ≤ 0.26 IgG index ≤ 0.88 Urine Glomerular filtration rate 70 – 140 mL/min Total protein < 0.2g/24h Albumin < 30 mg/24 h Calcium 2.5 – 7.5 mmol/24h Urobilinogen 1.7 – 5.9 µmol/24h Coproporphyrin < 300 nmol/24h Uroporphyrin 6 – 24 nmol/24h Delta-aminolevulinate 8 – 53 µmol/24h 5-hydroxyindoleacetic acid 10 – 47 µmol/24h Osmolality 350 – 1000 mosmol/Kg Faeces Nitrogen 70 – 140 mmol/24h Urobilinogen 50 – 500 µmol/24h Coproporphyrin 0.018 – 1.2 µmol/24h Coproporphyrin 0.46 mmol/g dry weight Protoporphyrin 0 – 4 µmol/24h Protoporphyrin 0 – 220 nmol/g dry weight Total porphyrin (ether soluble) 10 – 200 nmol/g dry weight (ether insoluble) 0 – 24 nmol/g dry weight Fat (on normal diet) < 7g / 24h This article comes from RxPG http://www.rxpgonline.com The Largest Community Website for Medical Students and Doctors The URL for this story is: http://www.rxpgonline.com/article185.html