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1) Amiodarone:

Choose 2 of the following options.

   1. Enhances the peripheral transformation of T4 to T3

   2. Inhibits TSH release

   3. Rarely causes corneal microdeposits

   4. Readily crosses the placenta

   5. Not given in pancreatic insufficiency

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2) Remifentanil:

Choose 2 of the following options.

   1. Will prevent the rise in intraocular pressure associated with the administration of suxamethonium.

   2. Will diminish cerebral vasoreactivity to carbon dixoide.

   3. Tends to cause a bradycardia.

   4. Provokes histamine release.

   5. Coronary blood flow is better than fentanyl/co2 anaesthesia

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3) Acetazolamide:

Choose 2 of the following options.

   1. Is used in the management of renal tubular acidosis

   2. Causes hypokalaemia

   3. Causes metabolic alkalosis

   4. Inhibits the action of carbonic anhydrase

   5. Causes hyponatremia

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4) Hepatic first-pass metabolism:

Choose 2 of the following options.

   1. Is avoided by giving a drug intranasally.

   2. Is avoided by giving a drug rectally.

   3. Is avoided by giving an intramuscular injection of a drug.

   4. Is seen when a drug has a low hepatic extraction ratio.

   5. Cant be 100% avaided by any route

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5) Epileptiform activity may be seen with:

Choose 2 of the following options.

   1. Propofol

   2. Neostigmine

   3. Etomidate

   4. Ketamine

   5. Metformin

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6) Hyperglycaemia may result from the administration of:

Choose 3 of the following options.

   1. Adrenaline

   2. Thyroid stimulating hormone

   3. Thiazide diuretics

   4. Beta blockers

   5. Alpha blockers

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7) Which of the following drugs readily cross the placenta?

Choose 2 of the following options.

   1. Physostigmine

   2. Suxamethonium

   3. Naloxone

   4. Heparin

   5. Thiazide

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8) Droperidol:

Choose 3 of the following options.

   1. Has alpha blocking activity.

   2. Is extensively metabolised by the liver.

   3. Causes extrapyramidal side effects.

   4. Is a phenothiazine.

   5. Has renal metabolism

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9) With regard to tramadol:

One answer only.

   1. Its effects can be largely reversed by naloxone.

   2. It is a potent respiratory depressant.

   3. It suppresses EEG activity at typically-used dosages.

   4. It is supplied as a racemic mixture of D and L forms.

   5. None of the above

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10) With regard to benzodiazepines which statements are correct?

Choose 3 of the following options.

   1. They inhibit release of gamma-aminobutyric acid.

   2. When used in premedicant doses,cardiovascular depression is uncommon.

   3. They possess analgesic properties.

   4. Nausea and vomiting are uncommon side effects.

   5. They have muscle relaxant properties