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RxPG :: View topic - Dna grooves  
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Author Message

mightchillout


DNA GROOVES
hi docs...

can someone explain to me the concept of major and minor grooves in DNA double helix???


i'm reaaly gettin confused on dis one

UNANSWERED: Am I too old(24) for mbbs?

super7
Aim USMLE Step 1

A groove is a depression..........so on the double-helix,on the side of the molecule there is a shallow depression and a deep depression which are respectively minor and major grooves......see lipinncott[the chap on DNA].

I also remember a drug used to combat cancerous cells,the name's Dactinomycin[Actinomycin D]which lodges itself in the minor groove and stops synthesis..........


mightchillout


i got the point... i had read dat from lippincott....

but i read from some other sources that the groove is basically defined as an angle between glycosidic bonds.... >180 is major and <180 id minor...

this is the confusin part

Essentials of Medical Pharmacology By KD Tripathi
Extensively revised and updated chapters to include recently introduced drugs, published information and therapeutic practices.
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Topic ID #64021
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