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RxPG :: View topic - Dna grooves  
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Author Message


hi docs...

can someone explain to me the concept of major and minor grooves in DNA double helix???

i'm reaaly gettin confused on dis one

UNANSWERED: Am I too old(24) for mbbs?

Aim USMLE Step 1

A groove is a depression..........so on the double-helix,on the side of the molecule there is a shallow depression and a deep depression which are respectively minor and major grooves......see lipinncott[the chap on DNA].

I also remember a drug used to combat cancerous cells,the name's Dactinomycin[Actinomycin D]which lodges itself in the minor groove and stops synthesis..........


i got the point... i had read dat from lippincott....

but i read from some other sources that the groove is basically defined as an angle between glycosidic bonds.... >180 is major and <180 id minor...

this is the confusin part

Essentials of Medical Pharmacology By KD Tripathi
Extensively revised and updated chapters to include recently introduced drugs, published information and therapeutic practices.
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